The Sapienza University of Rome also called simply Sapienza or the University of Rome, and formally the Università degli Studi di Roma "La Sapienza", is a public research university. located in Rome, Italy. It is one of the largest European Universities by enrollments and one of the oldest in history, founded in 1303. The university is one of the most prestigious Italian universities in the world, commonly ranking first in national rankings and in Southern Europe. In 2018, 2019, 2021 and 2022 it ranked first in the world for classics and ancient history.

Since the 2011 reform, Sapienza University of Rome has eleven faculties and 65 departments. Today Sapienza, with 140,000 students and 8,000 among academic and technical and administrative staff, is the largest university in Italy. The university has significant research programmes in the fields of engineering, natural sciences, biomedical sciences and humanities. It offers 10 Masters Programmes taught entirely in English.

The world's most important university rankings place Sapienza at the national top for quality of research, education and international dimension; moreover, Sapienza excels and leads as a benchmark in many subject areas.